Pelizaeus-Merzbacher disease

noun

Pel·​i·​zae·​us-Merz·​bach·​er disease ˌpel-ēt-ˈsā-əs-ˈmerts-ˌbäḵ-ər- 

: a progressive disease of the central nervous system that is marked by myelin degeneration resulting in deterioration of cognitive and motor functioning

Note: Pelizaeus-Merzbacher disease is a leukodystrophy with symptoms including involuntary eye movement, delayed development (as of motor skills and language), weak muscle tone, impaired coordination, and spasticity. It is inherited as an X-linked recessive trait requiring that both parents pass on a copy of the defective gene on the X chromosome.